Cisplatin-induced nephrotoxicity

Author: gdzh

August undefined, 2024

WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause acute kidney injury and chronic kidney disease. Preclinical studies have provided insights into the cellular … WebJun 1, 2024 · Cisplatin (CP) nephrotoxicity is a severe renal complication in patients receiving CP-based chemotherapy, but the incidence of AKI following CP chemotherapy …

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … WebThe major side effect of cisplatin is renal damage. Persea americana has been used in the Indian system of medicine to treat various diseases. This study aims to investigate the … diary\u0027s 4i

Cisplatin-induced nephrotoxicity in an outpatient setting

WebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk... WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebResults: The incidence of nephrotoxicity was 23.7% overall, with 8.1% of patients developing cisplatin-induced nephrotoxicity after the first dose. Patients who developed nephrotoxicity had a higher mean risk prediction score compared to patients who did not have nephrotoxicity (4.0 ± 2.0 versus 2.9 ± 2.1, p = 0.004, respectively). diary\\u0027s 4i

AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced ...

Activation and involvement of p53 in cisplatin-induced nephrotoxicity

WebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known … WebJan 3, 2024 · All of these drugs can affect the glomerulus, tubules, interstitium, or renal microvasculature via different mechanisms, with clinical manifestations that range from an asymptomatic elevation of serum creatinine and electrolyte disorders to acute kidney injury requiring dialysis. cities with similar climatesWebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. diary\u0027s 4h

"WebOct 26, 2024 · The Cisplatin-induced nephrotoxicity was evident from the elevated levels of creatinine, urea, uric acid, and renal tissue MDA and also decreased levels of SOD, CAT, GPX, and GSH in renal tissue. Administration of Gallic acid significantly modulated nephrotoxicity markers, gene expression variations, and histopathological damage. … " - Cisplatin-induced nephrotoxicity

Cisplatin-induced nephrotoxicity

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebFeb 5, 2014 · Nephrotoxicity caused by cisplatin is a well-known side effect and is dose-limiting toxicity that most commonly manifests as an acute and chronic impairment of renal function in almost all cisplatin-containing regimens. Nephrotoxicity appears to be clinical problem in 28–42% of patients treated with cisplatin in clinical practice ( 1–3 ). WebResults: The incidence of nephrotoxicity was 23.7% overall, with 8.1% of patients developing cisplatin-induced nephrotoxicity after the first dose. Patients who …

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WebFig. 2: The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA … WebThe aim of this study was to examine the effect of magnesium supplementation on the prevention of cisplatin-induced nephrotoxicity for patients with esophageal and hypopharyngeal cancer. Twenty-three patients with esophageal or hypopharyngeal cancer were studied over 2 weeks. Ten of them received magnesium supplementation and 13 …

WebCisplatin, a widely used chemotherapy drug, induces acute kidney injury, which limits its use and efficacy in cancer treatment. However, the molecular mechanism of cisplatin-induced nephrotoxicity is currently unclear. Using pharmacological and gene knockout models, we now demonstrate a pathological role for p53 in cisplatin nephrotoxicity. WebMar 9, 2024 · Cisplatin mediates nephrotoxicity via a number of different cytotoxic mechanisms. In addition to DNA damage, cisplatin also causes cytoplasmic organelle dysfunction, particularly in the endoplasmic reticulum and mitochondria, activates apoptotic pathways, and inflicts cellular damage via oxidative stress and inflammation [6].

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebDive into the research topics of 'Ethanol extract of Crataeva nurvala stem bark reverses cisplatin-induced nephrotoxicity'. Together they form a unique fingerprint. …

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Websuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH … cities with similar climate to seattleWebCisplatin toxicity arises most characteristically in the kidneys, cochlea, bone marrow, gastrointestinal mucosa and nerves (with altered taste, peripheral neuropathy and encephalopathy). The kidneys are particularly susceptible to cisplatin toxicity, as they are almost exclusively responsible for its excretion. diary\u0027s 4lWebsuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH ratio signiﬁcantly decreased with cisplatin treatment suggesting that cisplatin induced oxidative stress response in the kidney. GSH/oxidized GSH ratio is known to be an diary\\u0027s 4oWebThe major side effect of cisplatin is renal damage. Persea americana has been used in the Indian system of medicine to treat various diseases. This study aims to investigate the nephroprotective activity of hydroalchoholic extract of P. americana (HEPA) leaves on cisplatin induced nephrotoxicity in albino wistarrats. diary\\u0027s 4nWebBoldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats: Role of oxidative stress, inflammation and caspase-3 cities with sports teamsWebFeb 16, 2016 · Purpose: Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15–29 mL/min). However, although clinically important, in none of the randomized trials is grade 2 nephrotoxicity (defined as … cities with strange names diary\u0027s 4p