WebCre recombinase-mediated DNA recombination is an established method for conditional control of gene expression in animal models. Regulation of its activity has been … WebJan 24, 2024 · In breast cancer, ECM1 is essential for the ability of breast cancer cells to undergo matrix attachment, invasion, and metastasis by promoting mosin membrane translocation and phosphorylation . In gastric cancer, ECM1 can regulate gastric cancer cell metastasis and glucose metabolism by inducing the ITGB4/FAK/SOX2/HIF-1α signal …
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WebJun 10, 2024 · This translocation of Cre-recombinase surprisingly impairs proliferation (Figure 1B). EtOH treated gtRosaCreER T2 crypts grew linearly over a 4 days period, while 4-OHT significantly flattened the curve in a dose dependent manner. If treated with 1 µM 4-OHT the cell number even slightly decreased between day 2 and 4, indicating death of … WebOct 5, 2024 · Insulin stimulates glucose uptake in adipose tissue and skeletal muscle by inducing plasma membrane translocation of the glucose transporter GLUT4. Although the small GTPase Rac1 is a key regulator downstream of phosphoinositide 3-kinase (PI3K) and the protein kinase Akt2 in skeletal muscle, it remains unclear whether Rac1 also … raine \u0026 horne cowra
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WebAug 1, 1995 · The estimated frequency of Cre-mediated translocation between the nonhomologous mouse chromosomes is approximately 1 in 1200-2400 embryonic stem … WebThe Cre/lox system is a well-established research tool, especially in the field of mouse transgenics. A few of the most common uses are listed below. Cre-dependent gene expression – placing a stop codon with loxP sites … Cre-Lox recombination is a site-specific recombinase technology, used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented … See more Cre-Lox recombination is a special type of site-specific recombination developed by Dr. Brian Sauer and patented by DuPont that operated in both mitotic and non-mitotic cells, and was initially used in activating gene … See more During genetic recombination, a Holliday junction is formed between the two strands of DNA and a double-stranded break in a DNA molecule … See more The P1 phage is a temperate phage that causes either a lysogenic or lytic cycle when it infects a bacterium. In its lytic state, once its viral genome is injected into the host cell, viral … See more • Introduction to Cre-lox technology by the "Jackson Laboratory" See more Cre-Lox recombination involves the targeting of a specific sequence of DNA and splicing it with the help of an enzyme called Cre recombinase. Cre-Lox recombination is … See more Site-specific recombination (SSR) involves specific sites for the catalyzing action of special enzymes called recombinases. Cre, or cyclic … See more A classical strategy for generating gene deletion variants is based on double cross-integration of non-replicating vectors into the genome. … See more raine \u0026 horne commercial bankstown