Dynamo mapping vector field of single cells
WebFeb 2, 2024 · Researchers at the Whitehead Institute for Biomedical Research and other centers describe a computational approach called dynamo, which they used to retrace RNA velocity and single-cell transcriptomic "vector fields," and regulatory features from time-resolved single-cell RNA sequence data. "This framework represents a notable advance … WebDynamo: Mapping Transcriptomic Vector Fields of Single Cells. Inclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction, potential landscape mapping, differential geometry analyses, and most probably paths / in silico perturbation predictions. Installation - Ten minutes to dynamo - …
Dynamo mapping vector field of single cells
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WebDynamo: Mapping Transcriptomic Vector Fields of Single Cells. Inclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction, potential landscape mapping, … WebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions …
WebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions. WebJul 9, 2024 · Single-cell RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …
WebFeb 2, 2024 · Our analytical framework, dynamo, consists of four integral stages: 1) estimation of genome-wide kinetic rate constants and velocity vectors, 2) reconstruction of single-cell vector field functions with the resultant cell state and velocity samples, 3) in-depth analyses leveraging various differential geometry analyses, and 4) predictions of ... WebJul 9, 2024 · Here, we introduce dynamo, an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity …
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WebJul 9, 2024 · Here, we introduce dynamo , an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity vector fields that predict future cell fates, and finally employs differential geometry analyses to elucidate the underlying regulatory networks. dhs bakersfield caWebJul 9, 2024 · The reconstructed vector field further enables global mapping of potential landscapes that reflects the relative stability of a given cell state, and the minimal … dhs bartlesville oklahoma washington countyWebHome: Cell Press dhs basisinformation alkoholWeb•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell … dhs baltimore phone numberWebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - dynamo-release-Mapping-Vector-Field-of-... dhs bangor officeWebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, howev cincinnati bengals fan forumsWebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however, requires ... dhs bathrooms \\u0026 tiles hastings east sussex