Mycothiol acetyltransferase
Webmycothiol-dependent Glo1 from Streptomyces coelicolor. The enzyme has been determined to display a Ni2+-activation profile and indicates that Ni2+-activated Glo1 are indeed widespread in nature regardless of the intracellular thiol employed by an organism. Keywords: glyoxalase; nickel; streptomyces; mycothiol; metalloenzyme 1. Introduction Web3 mrt. 2024 · Back to the top
Mycothiol acetyltransferase
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WebCatalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
WebCatalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. WebCatalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
WebCatalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Specific Function Mycothiol synthase activity Pfam Domain Function … WebENZYME: 2.3.1.- ENZYME class: 2.3.1.- Release of 22-Feb-23 2.-.-.-: Transferases 2.3.-.-: Acyltransferases 2.3.1.-: Transferring groups other than amino-acyl groups All UniProtKB/Swiss-Prot entries corresponding to class 2.3.1.-. The following ENZYME entries belong to class 2.3.1.-:
WebIn the last reaction, catalyzed by the mshD -encoded mycothiol synthase, an acetyl group is added to the α-amino group of the cysteine, forming mycothiol [ Koledin02 ]. The genes encoding the different enzymes that are involved are scattered throughout the genome, and do not form an operon.
WebMycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy--D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacte-rium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glyco-syltransferase gene … ウェルネス 出店Web1 jan. 2005 · The biosynthesis of mycothiol occurs in four steps: (1) an uncharacterized coupling of myo-inositol and GlcNAc to generate the pseudo-disaccharide, (2) the … painel if goianoWeb1 jul. 2013 · Mpr1 belongs to the Gcn5-related N -acetyltransferase (GNAT) superfamily, but exhibits poor sequence homology with the GNAT enzymes and unique substrate specificity. Here, we present the X-ray crystal structure of Mpr1 and its complex with the substrate cis -4-hydroxy- l -proline at 1.9 and 2.3 Å resolution, respectively. ウエルネス医療クリニックWeb1 mei 2003 · The mshB gene encoding N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.Disruption of mshB in Mycobacterium smegmatis resulted in decreased production of mycothiol (5–10 % of the parent strain mc 2 155) but did not abolish mycothiol synthesis completely. . … painel ifrsWeb5 aug. 2002 · The crystal structure of the AAC (2′)-Ic from Mycobacterium tuberculosis has been determined in the apo enzyme form and in ternary complexes with CoA and either tobramycin, kanamycin A or... painel iffWebCatalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. painel ifsulWeb1 sep. 2003 · Mycothiol is the predominant low-molecular weight thiol produced by actinomycetes, including Mycobacterium tuberculosis. The last reaction in the biosynthetic pathway for mycothiol is catalyzed by mycothiol synthase (MshD), which acetylates the cysteinyl amine of cysteine-glucosamine-inositol (Cys-GlcN-Ins). painel ifind