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Shared eqtl

Webb26 jan. 2024 · The discovery of expression quantitative trait loci (eQTLs) and their target genes (eGenes) has not only compensated for the limitations of genome-wide association studies for complex phenotypes but has also provided a basis for predicting gene expression. Efforts have been made to develop analytical methods in statistical genetics, … Webb19 apr. 2016 · An example of a shared eQTL is RGR (Fig. 4d), which encodes a G protein-coupled receptor that is mutated in retinitis pigmentosa 47 ...

贝叶斯共定位软件coloc - 简书

Webb1 maj 2013 · Between the two environments 401 expression traits had an eQTL in both environments, of which 109 had an eQTL within 20 cM ( Table 1 and Figure 2 ). Of the 109 eQTL with a shared location between environments, 20 were among the 50 most significant eQTL in both environments. Webb23 nov. 2024 · To disentangle the shared eQTL signal for IL10RB and IFNAR2, we conducted phenome-wide association scans and pathway enrichment analysis, which suggested that IFNAR2 is more likely to play a role in COVID-19 hospitalization. Our findings prioritize trials of drugs targeting IFNAR2 and ACE2 for early management of … lannan auto linton https://thecykle.com

GWAS研究基本概念3——利用分子QTL和孟德尔随机化加强因果推 …

Webb20 juni 2024 · Enrichment for overlap with context-specific eQTL in liver or heart is generally higher than enrichment for significant eQTL overall, but the distribution of shared eQTL remains similar (Fig. 4c, Fig. 5d; Additional file 1: Table S7). Within a context, most eQTL do not overlap an enhancer, and there is wide variation in the number of eQTL ... Webb20 juli 2024 · An eQTL is commonly viewed as shared between tissues when the same SNP influences a gene in multiple tissues (GTEx Consortium 2015). Alternatively, two eQTLs can be viewed as shared if they influence expression of the same gene in multiple tissues, even though the SNP itself differs between tissues. Webb17 juli 2024 · For example, 30 genes shared an eQTL interaction between HAP1 and KRE33, 14 genes shared an eQTL interaction between HAP1 and MKT1, 13 genes shared an eQTL interaction between KRE33 with IRA2, and 14 genes shared eQTL interactions between GPA1 and the mating-type locus (Brem et al., 2005). assimmo

Integrative analysis of summary data from GWAS and eQTL …

Category:(PDF) Retinal ganglion cell-specific genetic regulation

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Shared eqtl

A fast and efficient colocalization algorithm for …

Webb16 juli 2024 · An expression quantitative trait locus (eQTL) is a genetic locus where sequence variation is associated with altered expression of one or more genes. eQTL … Webb18 jan. 2024 · The ratio of eQTL overlap between tissues depends on the similarity of biological functions, with more similar tissues sharing more eQTL . Our results support the significant overlap of eQTL between liver and muscle [see Additional file 5 : Figure S3], which could be due to the similarity of biological functions that regulate meat traits …

Shared eqtl

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Webb3 feb. 2024 · One approach is to use statistical colocalization to assess shared genetic aetiology across multiple related ... cis eQTL were defined 1MB upstream and … WebbSummary of kidney compartment-based eQTL analysis. a, Diagram indicating the work flow (and results) by which eGenes were identified in the tubular and glomerular compartment of human kidneys.b, Diagram illustrating the number of tubule-specific (top) and glomerulus-specific (bottom) eGenes identified by meta-analysis of eQTLs from 46 …

Webb4 dec. 2024 · 首先，无论是eQTL的数据，还是GWAS的数据，都是基于混合线性模型将基因型和性状给联系起来的。. 但是无论是eQTL的数据，还是GWAS的数据，一般就只能关联一种性状；那么共定位的目的就是要将某些关联到多个性状的snp给找出来. 而eQTL的优势是能够找到snp能够 ... Webb29 aug. 2024 · We found clusters of eQTL linked to shared functions across tissues and tissue-specific clusters linked to tissue-specific functions, driven by genetic variants with …

Webb目前做的最多的就是eQTL，即与基因表达水平的遗传变异。 血液是最常用的组织，其他都太难取了。 MolQTL通常分为 (1) 顺式作用 ，通常定义为1 Mb以内的基因调控；顺式作用通常很大，并且使用小样本量即可轻松发现。 (2) 反式作用 ，定义为影响基因更远或位于不同染色体上的molQTL。 反式效应往往小得多，并且需要更大的样本量。 基因转录水平是 … Webb3 juni 2024 · A line connecting two dots indicates a shared eQTL between different cell types. c , Empirical prior probability of eQTL sharing among three different myeloid cell …

Webb4 mars 2024 · We find strong evidence that the T cell eQTL and CD62L intensity trait association are shared, suggesting a distinct mode of regulation in different cell types …

WebbWe found that cis-eQTL signals (within 1 Mb of their target gene) were numerous, and many acted heterogeneously among regions and exons. Co-regulation analysis of shared eQTL signals produced well-defined modules of region-specific co-regulated genes, in contrast to standard coexpression analysis of the same samples. lannanlevityssopimusWebb13 dec. 2011 · Summary: seeQTL is a comprehensive and versatile eQTL database, including various eQTL studies and a meta-analysis of HapMap eQTL information. The … lannankieliWebb14 maj 2024 · Recently, eQTL have been identified using a broad collection of normal human tissues from diverse populations, increasing our understanding of regulation of … lannan autoWebb27 juni 2024 · We next addressed the degree of sharing of the local genetic control of gene expression in the two classes of disease (namely JIA and IBD) by performing comparative eQTL analysis. Whole genome genotypes were ascertained on the Immunochip (CD and UC samples) or the Affymetrix Axiom Biobank array (see the “ Methods ” section). lannanlevitinWebb28 juli 2024 · We show evidence for the shared genetic basis of neonatal eQTLs and reQTLs with common autoimmune and allergic diseases, and many of such … assim.netWebbshared eQTL 16. In keeping with this, conditional eQTL (sec-ondary, tertiary and quaternary eQTL) in NK cells are enriched for enhancers ( p = 0.0018), but show no enrichment around lannan eacottWebb14 juli 2024 · shared eQTL amongst related cell types, such as subpopulations belonging to the RGC. lineage, specifically RGC1, RGC2, RGC3 and RPC9, which share eQTL for 58 eGenes (Figure 2B, C). lannan laajaperäisyys